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A.M. Vitals: Liver Warning For Glaxo's Alli and Xenical Weight-Loss Drugs Wall Street Journal (blog)

Liver Warning : The labels of GlaxoSmithKline’s diet drugs Alli and Xenical will warn users of potential liver problems though the FDA hasn’t established that the drugs actually cause injury, Dow Jones Newswires reports . The warnings will advise people taking orlistat — the active ingredient in both drugs — to be on the lookout for itching, yellow eyes or skin, dark urine and loss of appetite, all of which are symptoms of liver problems. BNET’s Pharma Analysis blog noted yesterday that the FDA’s investigation actually turned up fewer cases of reported liver problems than it originally thought and that GSK doesn’t believe the mechanism of the drug could result in damage.

E. Coli Threat : Six lesser-known strains of the E. coli bacteria are getting new scrutiny after a recent food-poisoning outbreak linked to tainted lettuce, the New York Times reports . While foods are often screened for the infamous E. coli O157:H7, lawmakers may now push to test for other toxic strains as well. The meat industry says outbreaks caused by those other strains haven’t been “definitively” tied to beef and that its own anti-contamination measures are sufficient.

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